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Andrew S. Peregrine

Andrew Peregrine Picture

Associate Professor

BVMS, PhD, DVM, Diplomate EVPC, Diplomate ACVM (Veterinary Parasitology)

 aperegri@uoguelph.ca
 Office: PAHL 3825
 519-824-4120 Ext. 54714

 Lab: PAHL 3808
 519-824-4120 Ext. 53616

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Andrew Peregrine obtained his BVMS, PhD and DVM from the University of Glasgow, Scotland. He then worked for 9 years as a research scientist at the International Laboratory for Research on Animal Diseases, Nairobi, Kenya, where he carried out research to improve control of tropical parasites of cattle. Since 1997 he has been an Associate Professor in clinical parasitology at the Ontario Veterinary College, University of Guelph, where he teaches DVM students in all years of the program. In addition, his research interests currently include emerging zoonotic parasite infections of companion animals, and sustainable control of gastro-intestinal parasites of sheep. He is a diplomate of the European Veterinary Parasitology College and the American College of Veterinary Microbiologists.

Research Interests

Epidemiology and impact of parasite infections. Emerging parasitic zoonoses. Sustainable control of gastrointestinal parasites of sheep.

Research projects are currently being carried out with the following objectives:

  • Describe the immune response of replacement ewes to Haemonchus contortus infection over their first and second grazing seasons in Ontario;
  • Evaluate the utility of the carbohydrate larval antigen (CarLA®) saliva test to lower the risk of gastrointestinal parasitism in Ontario sheep flocks
  • Determine if drug-resistant strains of Dirofilaria immitis (heartworm) are present in Ontario dogs;
  • Determine the prevalence of Echinococcus multilocularis in wild canids in southern Ontario;
  • Identify high risk areas or “hot spots” for Echinococcus multilocularis infection in southern Ontario wild canids;
  • Determine the prevalence of Echinococcus multilocularis in dogs visiting off-leash dog parks in the Golden Horseshoe region of southern Ontario.

Overview of research projects in Clinical Parasitology - Peregrine Lab (poster)

Current Graduate Students

  • Bradley De Wolf - PhD

Teaching

  • DVM program:
  • VETM*3410 - Health Management II
  • VETM*4460 - Food Animal Medicine and Surgery
  • VETM*4470 – Medicine and Surgery – Dog and Cat
  • VETM*4420 - Clinical Pharmacology
  • VETM*4530 - Advanced Health Management for Companion Animals
  • VETM*4530 - Advanced Health Management for Horses
  • VETM*4530 - Advanced Health Management for Small Ruminants
  • Phase 4 - Veterinary Diagnostic Pathology Core Rotation
  • Phase 4 - Small Ruminant Elective
  • Phase 4 - Equine Primary Care Elective
  • Other teaching:
  • ONEH*1000 - Introduction to One Health
  • POPM*4040 - Epidemiology of food-borne diseases
  • BIOM*4090 - Pharmacology
  • POPM*6300 - Epidemiology of zoonoses

Professional Experience & Honours

2014-2015: President of the American Association of Veterinary Parasitologists (AAVP).

2015 Ontario Veterinary College “Year ‘68” Award for Teaching Excellence.

2016 Ontario Veterinary College “Year ‘68” Award for Teaching Excellence.

2017 Broad Spectrum LGBTQ+ Veterinary Awareness Award

2021 AAVP/Boehringer Ingelheim Distinguished Veterinary Parasitologist Award

2023 Zoetis Carl J. Norden Distinguished Teacher Award

Selected Publications

  • Jeeves, S.P., Kotwa, J.D., Stevens, B., Shirose, L., Cai, H.Y., Peregrine, A.S., Mubareka, S., Jardine, C.M. (2024) Additional diagnoses of Echinococcus multilocularis in eastern chipmunks (Tamias striatus) from southern Ontario - results from ongoing surveillance for E. multilocularis in intermediate hosts in Ontario, Canada. Veterinary Parasitology: Regional Studies and Reports 48, 100982. https://doi.org/10.1016/j.vprsr.2024.100982
  • Charlebois, P.R., Bersenas, A.M., Yiew, X.T., Weese, J.S., Peregrine, A.S. (2023) Local outbreak of spontaneous pneumothorax secondary to paragonimosis in southwestern Ontario dogs. Canadian Veterinary Journal 64, 643-649. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286141/
  • Evason, M.D., Jenkins, E.J., Kolapo, T.U., Mitchell, K.D., Leutenegger, C.M., Peregrine, A.S. (2023) Novel molecular diagnostic (PCR) diagnosis and outcome of intestinal Echinococcus multilocularis in a dog from western Canada. Journal of the American Veterinary Medical Association, pages 1-3. https://doi.org/10.2460/javma.23.03.0179
  • French, S.K., Kotwa, J.D., Singh, B., Greer, T., Pearl, D.L., Elsemore, D.A., Hanna, R., Jardine, C.M., Weese, J.S., Mercer, N., Peregrine, A.S. (2023) Factors associated with Giardia infection in dogs in southern Ontario, Canada. Veterinary Parasitology: Regional Studies and Reports 41, 100870. https://authors.elsevier.com/a/1gy5g8Z31KqJDG
  • Dixon, S., Karrow, N.A., Borkowski, E., Suarez-Vega, A., Menzies, P.I., Kennedy, D., Peregrine, A.S., Mallard, B.A., Cánovas, A. (2023) Identifying hepatic genes regulating the ovine response to gastrointestinal nematodes using RNA-Sequencing. Frontiers in Genetics, section Livestock Genomics, 14, 1111426. https://www.frontiersin.org/articles/10.3389/fgene.2023.1111426/full
  • Kolapo, T.U., Hay, A., Gesy, K.M., Frey, C.F., Rothenburger, J.L., Joffe, D.J., Spotswood, T., Huang, Y., Massolo, A., Peregrine, A.S., Hill, J.E., Jenkins, E.J. (2023) Canine alveolar echinococcosis: an emerging and costly introduced problem in North America. Transboundary and Emerging Diseases, volume 2023, Article ID 5224160. https://doi.org/10.1155/2023/5224160
  •  DeWinter, S., Bauman, C., Peregrine, A., Weese, J.S., Clow, K.M. (2023) Infestation patterns of Ixodes scapularis and Dermacentor variabilis on dogs and cats across Canada. PLOS ONE 18(2), e0281192. https://doi.org/10.1371/journal.pone.0281192
  • DeWinter, S., Bauman, C., Peregrine, A., Weese, J.S., Clow, K.M. (2023) Assessing the spatial and temporal patterns and risk factors for acquisition of Ixodes spp. by companion animals across Canada. Ticks and Tick-borne Diseases 14, 102089. https://www.sciencedirect.com/science/article/pii/S1877959X22001911?via%3Dihub
  • Maggi, R.G., Halls, V., Krämer, F., Lappin, M., Pennisi, M.G., Peregrine, A.S., Roura, X., Schunack, B., Scorza, V., Tasker, S., Baneth, G., Bourdeau, P., Bowman, D.D., Breitschwerdt, E.B., Capelli, G., Cardoso, L., Dantas-Torres, F., Dobler, G., Ferrer, L., Gradoni, L., Irwin, P., Jongejan, F., Kempf, V.A.J., Kohn, B., Little, S., Madder, M., Maia, C., Marcondes, M., Miró, G., Naucke, T., Oliva, G., Otranto, D., Penzhorn, B.L., Pfeffer, M., Sainz, Á., Shin, SS., Solano-Gallego, L., Straubinger, R.K., Traub, R., Wright, I. (2022) Vector-borne and other pathogens of potential relevance disseminated by relocated cats. Parasites & Vectors 15, 415 (15 pages) https://doi.org/10.1186/s13071-022-05553-8
  • French, S.K., Pearl, D.L., Sutton, W.B., Peregrine, A.S., Jardine, C.M. (2022) Environmental factors associated with Baylisascaris procyonis infection from a population of raccoons in Toronto, Ontario, Canada. Urban Ecosystems 25, 691-703 (12 pages). https://doi.org/10.1007/s11252-021-01177-5
  • French, S.K., Pearl, D.L., Stevens, B., Peregrine, A.S., M. Jardine, C.M. (2021) Morbidity and mortality in Ontario rodents and lagomorphs: A 30-year retrospective review. Journal of Wildlife Diseases 57, 874-883. https://doi.org/10.7589/JWD-D-20-00106
  • Kotwa, J.D., French, S.K., Greer, T., Elsemore, D.A., Hanna, R., Jardine, C.M., Pearl, D.L., Weese, J.S., Mercer, N., Peregrine. A.S. (2021) Prevalence of intestinal parasites in dogs in southern Ontario, Canada, based on fecal samples tested using sucrose double centrifugation and Fecal Dx® tests. Veterinary Parasitology: Regional Studies and Reports 26, 100618. https://doi.org/10.1016/j.vprsr.2021.100618
  • Kotwa, J.D., Schnyder, M., Jardine, C.M., Deplazes, P., Pearl, D.L., Berke, O., Mercer, N., Peregrine, A.S. (2021) Investigation of the occurrence of Angiostrongylus vasorum in coyotes in southern Ontario, Canada. Journal of Veterinary Diagnostic Investigation 33, 664-669. https://doi.org/10.1177%2F10406387211011990
  • Kotwa, J.D., Greer, T., Jardine, C.M., Weese, J.S., Isaksson, M., Pearl, D.L., Berke, O., Mercer, N., Peregrine. A.S. (2020) Evaluation of the prevalence of Echinococcus multilocularis in dogs that visit off-leash dog parks in southern Ontario, Canada. Zoonosis and Public Health 2020;00:1-5. https://doi.org/10.1111/zph.12792
  • Hart, E., Singh, A., Peregrine, A., Sanchez, A., zur Linden, A., Jensen, M., Appleby, R., Hagen, C.R.M., Wan, J., Larose, P. (2020) Laparoscopic ureteronephrectomy for the treatment of giant kidney worm infection in 2 dogs. Canadian Veterinary Journal 61, 1149-1154.
  • Borkowski, E.A., Avula, J., Redman, E.M., Sears, W., Lillie, B.N., Karrow, N.A., Menzies, P.I., Gilleard, J.S., Peregrine, A.S. (2020) Correlation of subclinical gastrointestinal nematode parasitism with growth and reproductive performance in ewe lambs in Ontario. Preventive Veterinary Medicine 185, 105175. https://doi.org/10.1016/j.prevetmed.2020.105175
  • French, S.K., Pearl, D.L., Peregrine, A.S., Jardine, C.M. (2020) Spatio-temporal clustering of Baylisascaris procyonis, a zoonotic parasite, in raccoons across different landscapes in southern Ontario. Spatial and Spatio-temporal Epidemiology 35, 100371. https://doi.org/10.1016/j.sste.2020.100371
  • Zajac, A., Fairman, D., McGee, E., Wells, B., Peregrine, A., Jenkins, E., LeRoith, T., St John, B. (2020) Alveolar echinococcosis in a dog in the eastern United States. Journal of Veterinary Diagnostic Investigation 32, 742-746. https://doi.org/10.1177/1040638720943842
  • Borkowski, E.A., Avula, J., Karrow, N.A., Menzies, P.I., Sears, W., Redman, E.M., Lillie, B.N., Gilleard, J.S., Peregrine, A.S. (2020) Correlation of salivary antibody to carbohydrate larval antigen (CarLA) with health and gastrointestinal nematode parasitism in sheep under Ontario grazing conditions. Veterinary Parasitology 283, 109183. https://doi.org/10.1016/j.vetpar.2020.109183
  • Kotwa, J.D., Jardine, C.M., Pearl, D.L., Berke, O., Mercer, N.J., Peregrine, A.S. (2020) Evaluation of the SNAP® 4Dx® plus test for the detection of Dirofilaria immitis antigen and characterization of exposure to tick-borne pathogens in wild canids in southern Ontario. Veterinary Parasitology 283, 109176. https://doi.org/10.1016/j.vetpar.2020.109176
  • Borkowski, E.A., Redman, E.M., Chant, R., Avula, J., Menzies, P.I., Karrow, N.A., Lillie, B.N., Sears, W., Gilleard, J.S., Peregrine, A.S. (2020) Comparison of ITS-2 rDNA nemabiome sequencing with morphological identification to quantify gastrointestinal nematode community species composition in small ruminant feces. Veterinary Parasitology 282, 109104. https://doi.org/10.1016/j.vetpar.2020.109104
  • French, S.K., Pearl, D.L., Shirose, L., Peregrine, A.S., Jardine, C.M. (2020) Demographic and environmental factors associated with Baylisascaris procyonis infection of raccoons (Procyon lotor) in Ontario, Canada. Journal of Wildlife Diseases 56, 328-337.
  • Kotwa, J.D., Pearl, D.L., Isaksson, M., Jardine, C.M., Berke, O., Mercer, N.J., Osterman-Lind, E., Peregrine, A.S. (2020) Factors associated with Echinococcus multilocularis infection in coyotes in southern Ontario. Zoonoses and Public Health 2020;00:1-8. https://doi.org/10.1111/zph.12718
  • Dantas-Torres, F., Mirò, G., Baneth, G., Bourdeau, P., Breitschwerdt, E., Capelli, G., Cardoso, L., Day, M.J., Dobler, G., Ferrer, L., Irwin, P., Jongejan, F., Kempf, V.A.J., Kohn, B., Lappin, M., Little, S., Madder, M., Maggi, R., Maia, C., Marcondes, M., Naucke, T., Oliva, G., Pennisi, M.G., Penzhorn, B.L., Peregrine, A., Pfeffer, M., Roura, X., Sainz, A., Shin, SS., Solano-Gallego, L., Straubinger, R.K., Tasker, S., Traub, R., Wright, I., Bowman, D.D., Gradoni, L., Otranto, D. (2019) Canine Leishmaniasis Control in the Context of One Health. Emerging Infectious Diseases 25, e1-e4. https://doi.org/10.3201/eid2512.190164
  • Kotwa, J.D., Jardine, C.M., Berke, O., Pearl, D.L., Mercer, N.J., Peregrine, A.S. (2019) Prevalence and distribution of Dirofilaria immitis infection in wild canids in southern Ontario. Veterinary Parasitology: Regional Studies and Reports 18, 100349, pages 1-4. https://doi.org/10.1016/j.vprsr.2019.100349
  • Pinard, C., Cuq, B., Gibson, T., Brisson, B., Plattner, B., Lillie, B., Bienzle, D., Brouwer, E., Gottstein, B., Peregrine, A. (2019) Alveolar echinococcosis in an Ontario dog resembling an hepatic abscess. Canadian Veterinary Journal 60, 1099-1103. PMCID:PMC6741825
  • Ogden, N.H., Bouchard, C., Badcock, J., Drebot, M.A., Elias, S.P., Hatchette, T.F., Koffi, J.K., Leighton, P.A., Lindsay, L.R., Lubelczyk, C.B., Peregrine, A.S., Smith, R.P., Webster, D. (2019) What is the real number of Lyme disease cases in Canada? BMC Public Health 18:849. https://doi.org/10.1186/s12889-019-7219-x
  • McGill, E., Berke, O., Weese, J.S., Peregrine, A. (2019) Heartworm infection in domestic dogs in Canada, 1977-2016: Prevalence, time trend, and efficacy of prophylaxis. Canadian Veterinary Journal 60, 605-612. PMCID: PMC6515813
  • McGill, E., Berke, O., Peregrine, A.S., Weese, J.S. (2019) Epidemiology of canine heartworm (Dirofilaria immitis) infection in domestic dogs in Ontario, Canada: geographic distribution, risk factors and effects of climate. Geospatial Health 14, 17-24. https://doi.org/10.4081/gh.2019.741
  • French, S.K., Pearl, D.L., Peregrine, A.S., Jardine, C.M. (2019) Baylisascaris procyonis infection in raccoons: a review of demographic and environmental factors influencing parasite carriage. Veterinary Parasitology: Regional Studies and Reports 16, 100275, 1-8. https://doi.org/10.1016/j.vprsr.2019.100275
  • Evason, M., Stull, J.W., Pearl, D.L., Peregrine, A.S., Jardine, C., Buch, J.S., Lailer, Z., O'Connor, T., Chandrashekar, R., Weese, J.S. (2019) Prevalence of Borrelia burgdorferi, Anaplasma spp., Ehrlichia spp. and Dirofilaria immitis in Canadian dogs, 2008 to 2015: a repeat cross-sectional study. Parasites & Vectors 12: 64. https://doi.org/10.1186/s13071-019-3299-9
  • James, C.A., Pearl, D.L., Lindsay, L.R., Peregrine, A.S., Jardine, C.M. (2019) Risk factors associated with the carriage of Ixodes scapularis relative to other tick species in a population of pet dogs from southeastern Ontario, Canada. Ticks and Tick-borne Diseases 10, 290-298. https://doi.org/10.1016/j.ttbdis.2018.10.004
  • Kotwa, J.D., Isaksson, M., Jardine, C.M., Campbell, G.D., Berke, O., Pearl, D.L., Mercer, N.J., Osterman-Lind, E., Peregrine, A.S. (2019) Echinococcus multilocularis infection, Southern Ontario, Canada. Emerging Infectious Diseases 25, 265-272. https://doi.org/10.3201/eid2502.180299
  • Milnes, E., Delnatte, P., Dutton, C.J., Brouwer, E., Cai, H.Y, Smith, D.A., Peregrine, A.S. (2018) Echinococcus equinus hydatid cyst in the liver of a Przewalski’s horse (Equus przewalskii) in a Canadian zoo. Journal of Zoo and Wildlife Medicine 49, 1047-1050. https://doi.org/10.1638/2018-0072.1
  • French, S.K., Jajou, S., Campbell, G.D., Cai, H.Y., Kotwa, J.D., Peregrine, A.S., Jardine, C.M. (2018) Echinococcus multilocularis in a wild free-living eastern chipmunk (Tamias striatus) in Southern Ontario: A case report and subsequent field study of wild small mammals. Veterinary Parasitology: Regional Studies and Reports 13, 234-237. https://doi.org/10.1016/j.vprsr.2018.06.009
  • Minigan, J.N., Hager, H.A., Peregrine, A.S., Newman, J.A. (2018) Current and potential future distribution of the American dog tick (Dermacentor variabilis, Say) in North America. Ticks and Tick-Borne Diseases 9, 354-362. https://doi.org/10.1016/j.ttbdis.2017.11.012
  • Swirski, A.L., Pearl, D.L., Peregrine, A.S., Thomas, J., Pintar, K. (2017) Temporal trends in Giardia occurrence in the Grand River and surrounding tributaries, Waterloo, Ontario (2005-2013), a retrospective analysis of surveillance data. Zoonoses and Public Health 2017;00:1-13. https://doi.org/10.1111/zph.12388
  • Westers, T., Jones-Bitton, A., Menzies, P., VanLeeuwen, J., Poljak, Z., Peregrine, A.S. (2017) Comparison of targeted selective and whole flock treatment of periparturient ewes for controlling Haemonchus sp. on sheep farms in Ontario, Canada. Small Ruminant Research 150, 102-110.
  • Herrin, B.H., Peregrine, A.S., Goring, J., Beall, M.J., Little, S.E. (2017) Canine infection with Borrelia burgdorferi, Dirofilaria immitis, Anaplasma spp. and Ehrlichia spp. in Canada, 2013-2014. Parasites and Vectors 10:244. https://doi.org/10.1186/s13071-017-2184-7
  • Trotz-Williams, L.A., Mercer, N.J., Walters, J.M., Wallace, D., Gottstein, B., Osterman-Lind, E., Boggild, A.K., Peregrine, A.S. (2017) Public health follow-up of suspected exposure to Echinococcus multilocularis in southwestern Ontario. Zoonoses and Public Health 64, 460-467. https://doi.org/10.1111/zph.12326
  • Westers, T., Jones-Bitton, A., Menzies, P., VanLeeuwen, J., Poljak, Z., Peregrine, A.S. (2016) Identification of effective treatment criteria for use in targeted selective treatment programs to control haemonchosis in periparturient ewes in Ontario, Canada. Preventive Veterinary Medicine 134, 49-57. https://doi.org/10.1016/j.prevetmed.2016.09.021
  • Westers, T., Jones-Bitton, A., Menzies, P., Van Leeuwen, J., Poljak, Z., Peregrine, A.S. (2016) Efficacy of closantel against ivermectin- and fenbendazole-resistant Haemonchus sp. in sheep in Ontario, Canada. Veterinary Parasitology 228, 30-41. https://doi.org/10.1016/j.vetpar.2016.08.009
  • Nielsen, M.K., von Samson-Himmelstjerna, G., Pfister, K., Reinemeyer, C.R., Molento, M.B., Peregrine, A.S., Hodgkinson, J.E., Jacobsen, S., Kaplan, R.M., Matthews, J.B. (2016) The appropriate antiparasitic treatment: coping with emerging threats from old adversaries. Equine Veterinary Journal 48, 374-375. https://doi.org/10.1111/evj.12550
  • Swirksi, A.L., Pearl, D.L., Peregrine, A.S., Pintar, K. (2016) A comparison of exposure to risk factors for giardiasis in non-travellers, domestic travellers and international travellers in a Canadian community, 2006-2012. Epidemiology and Infection 144, 980-999. https://doi.org/10.1017/s0950268815002186
  • Peregrine, A.S. (2015) Alveolar echinococcosis in dogs: an emerging issue? The Veterinary Record 177, 567-568. https://doi.org/10.1136/vr.h6551
  • Leonard, E.K., Pearl, D.L., Janecko, N., Finley, R.L., Reid-Smith, R.J., Weese, J.S., Peregrine, A.S. (2015) Risk factors for carriage of antimicrobial-resistant Salmonella spp and Escherichia coli in pet dogs from volunteer households in Ontario, Canada, in 2005 and 2006. American Journal of Veterinary Research 76, 959-968. https://doi.org/10.2460/ajvr.76.11.959
  • Bouchard, C., Leonard, E., Koffi, J.K., Pelcat, Y., Peregrine, A., Chilton, N., Rochon, K., Lysyk, T., Lindsay, L.R., Ogden, N.H. (2015) The increasing risk of Lyme disease in Canada. Canadian Veterinary Journal 56, 693-699. PMCID: PMC4466818
  • Bourguinat, C., Lee, A.C.Y., Lizundia, R., Blagburn, B.L., Liotta, J.L., Kraus, M.S., Keller, K., Epe, C., Letourneau, L., Kleinman, C.L., Paterson, T., Gomez, E.C., Montoya-Alonso, J.A., Smith, H., Bhan, A., Peregrine, A.S., Carmichael, J., Drake, J., Schenker, R., Kaminsky, R., Bowman, D.D., Geary, T.G., Prichard, R.K. (2015) Macrocyclic lactone resistance in Dirofilaria immitis: Failure of heartworm preventives and investigation of genetic markers for resistance.  Veterinary Parasitology 210, 167-178. https://doi.org/10.1016/j.vetpar.2015.04.002
  • Oscos-Snowball, A., Tan, E., Peregrine, A.S., Foster, R., Bronsoiler, J., Gottstein, B., Jenkins, E., Gesy, K., Bienzle, D. (2015) What is your diagnosis? Fluid aspirated from an abdominal mass in a dog. Veterinary Clinical Pathology 44, 167-168. https://doi.org/10.1111/vcp.12210

Search PubMed for additional publications by Dr. Peregrine.